| QB |
| Josh Allen | Buf | 33.36 | Passing 329 Yds, 3 TD Rushing 32 Yds, 1 Fum |
| RB1 |
| Joe Mixon | Cin | 16.80 | Rushing 45 Yds Receiving 4 Rec, 23 Yds, 1 TD |
| RB2 |
| Breece Hall | NYJ | 22.10 | Rushing 116 Yds, 1 TD Receiving 2 Rec, 5 Yds |
| WR1 |
| Drake London | Atl | 7.00 | |
| WR2 |
| Devin Duvernay | Bal | 2.40 | |
| TE |
| Irv Smith Jr. | Min | 10.70 | Receiving 4 Rec, 7 Yds, 1 TD |
| FLEX |
| Tyler Lockett | Sea | 3.70 | |
| D |
| Bills D/ST | Buf | 9.00 | |
| K |
| Matt Gay | Ind | 6.00 | |
| Ben1 |
| Davante Adams | LV | 0.00 | |
| Ben2 |
| David Montgomery | Det | 9.00 | Rushing 67 Yds Receiving 1 Rec, 13 Yds |
| Ben3 |
| Dalton Schultz | Hou | 0.00 | |
| Ben4 |
| Cordarrelle Patterson | Atl | 0.00 | |
| Ben5 |
| Michael Carter | NYJ | 5.70 | Rushing 41 Yds Receiving 1 Rec, 6 Yds |
| Ben6 |
| Isaiah McKenzie | FA | 2.90 | |
| Ben7 |
| Deon Jackson | Ind | 28.10 | Rushing 42 Yds, 1 TD Receiving 10 Rec, 79 Yds |