| Round | Pick | Name | Starts | Points | PPG |
|---|---|---|---|---|---|
| 1 | 4 | Justin Jefferson | 16 | 309.08 | 18.18 |
| 2 | 17 | Derrick Henry | 16 | 321.30 | 18.90 |
| 3 | 24 | Brandon Aiyuk | 2 | 62.40 | 8.91 |
| 4 | 37 | Jalen Hurts | 14 | 343.12 | 20.18 |
| 5 | 44 | Drake London | 13 | 240.10 | 14.12 |
| 6 | 57 | David Montgomery | 12 | 224.72 | 13.22 |
| 7 | 64 | George Kittle | 14 | 231.90 | 13.64 |
| 8 | 77 | Tony Pollard | 7 | 198.50 | 11.68 |
| 9 | 84 | Xavier Worthy | 3 | 187.20 | 11.01 |
| 10 | 97 | Ladd McConkey | 5 | 224.40 | 13.20 |
| 11 | 104 | Gus Edwards | 0 | 12.50 | 3.13 |
| 12 | 117 | Curtis Samuel | 0 | 4.80 | 2.40 |
| 13 | 124 | Harrison Butker | 9 | 79.00 | 7.90 |
| 14 | 137 | 49ers D/ST | 10 | 102.00 | 6.80 |
| 15 | 144 | Adam Thielen | 12 | 130.10 | 7.65 |
| 16 | 157 | Quentin Johnston | 2 | 96.10 | 7.39 |